Research suggests a link between male infertility and autism
New research results suggest there is a slightly increased risk of autism in children born to patients previously diagnosed with infertility, regardless of whether they received fertility treatment or not.
A recent study published in JAMA Network Open has shed light on a possible connection between parents’ fertility problems and a slightly elevated risk of Autism Spectrum Disorder (ASD) in their children. The research, led by Dr. María Vélez of the Department of Obstetrics and Gynecology, examined more than 1.3 million children born in Ontario between 2006 and 2018.
The increase in infertility diagnoses has led to significant growth in publicly funded fertility programs in Canada, providing broader access to fertility treatments. However, this study highlights the need to better understand the health implications for mothers and children who participate in these programs.
The study results show that children born to parents diagnosed with fertility problems have a slightly increased risk of ASD. The research classified children according to the mode of conception, from natural conceptions to various fertility treatments, such as in vitro fertilization.
During a 5- to 11-year follow-up starting at 18 months of age, ASD was diagnosed in 1.6% of children, with incidence rates specific to the method of conception. Children conceived through fertility treatments had higher rates of ASD compared to those conceived naturally.
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Dr. Vélez highlights that some obstetric factors, such as premature birth or having twins or triplets, also played a significant role in the association between parental infertility and ASD. These results suggest the importance of specifically addressing these factors to reduce associated risks.
“The findings support the need to continue efforts to minimize multiple pregnancies and prevent preterm birth after fertility treatments,” says Dr. Vélez. Additionally, he highlights the importance of providing early care plans for pregnant patients who have received fertility treatments, with the goal of mitigating potential adverse outcomes in this population.
Although the study offers insightful insight, Dr. Vélez emphasizes the need for additional research to fully understand the underlying mechanisms. More detailed analyses are required regarding the initial diagnosis of infertility, specific paternal factors, and the origin of the eggs or sperm used in treatment.
In conclusion, this study raises intriguing questions about the intersection between parental infertility and the risk of ASD in their children. As this area of research continues, it is hoped that more effective strategies will be developed to minimize risks and improve the health of mothers and children participating in fertility treatments.
